Maintenance of contractile function of isolated airway smooth muscle after cryopreservation
نویسندگان
چکیده
منابع مشابه
The contractile apparatus and mechanical properties of airway smooth muscle.
The functional properties of airway smooth muscle are fundamental to the properties of the airways in vivo. However, many of the distinctive characteristics of smooth muscle are not easily accounted for on the basis of molecular models developed to account for the properties of striated muscles. The specialized ultrastructural features and regulatory mechanisms present in smooth muscle are like...
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Chronic contractile activation, or tone, in asthma coupled with continuous stretching due to breathing may be involved in altering the contractile function of airway smooth muscle (ASM). Previously, we (11) showed that cytoskeletal remodeling and stiffening responses to acute (2 h) localized stresses were modulated by the level of contractile activation of ASM. Here, we investigated if altered ...
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The important pathophysiological features of the airways in asthma include exaggerated narrowing to bronchoconstrictor agonists and attenuated relaxation to beta adrenoceptor stimulation. These physiological perturbations are associated with inflammation and remodelling of the airways, the latter including an increase in airway smooth muscle cell mass, disruption of the airway epithelium, and c...
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Progress toward understanding the physiology of smooth muscle has been slow for several reasons. In most smooth muscle tissues, the cells are extremely small, electrically coupled to one another, often spontaneously active and complexed with large amounts of inelastic connective tissue. The technical problems posed by these factors are numerous and have been reviewed extensively (Tomita, 1970; ...
متن کاملStudies on isolated smooth muscle cells: The contractile apparatus.
Smooth muscle cells may be isolated from the taenia coli muscle of the guinea pig which, when made permeable by treatment with Triton X-100 (0-05%) show a sensitivity to Ca for contraction with MgATP. The rate of contraction, about 10 micron s-1, corresponds closely to the maximum velocity of shortening of the intact muscle. Electron microscopy of such partially demembranated muscle cells shows...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Lung Cellular and Molecular Physiology
سال: 2018
ISSN: 1040-0605,1522-1504
DOI: 10.1152/ajplung.00064.2018